3/10/2024 0 Comments Silvadene cream para que sirve![]() Renal impairment: Use with caution in patients with renal impairment sulfadiazine may accumulate.Hepatic impairment: Use with caution in patients with hepatic impairment sulfadiazine may accumulate.G6PD deficiency: Use with caution in patients with G6PD deficiency hemolysis may occur.Systemic effects: Systemic absorption may be significant and adverse reactions may occur.Fungal proliferation may rarely occur in and below the eschar. difficile-associated diarrhea (CDAD) and pseudomembranous colitis CDAD has been observed >2 months postantibiotic treatment. Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C.Use in patients with sulfonamide allergy is specifically contraindicated in product labeling, however, a risk of cross-reaction exists in patients with allergy to any of these compounds avoid use when previous reaction has been severe. Sulfonamide allergy: Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, and loop diuretics (except ethacrynic acid).Renal: Interstitial nephritis Warnings/Precautions Hypersensitivity: Hypersensitivity reaction (may be related to sulfa component) Hematologic & oncologic: Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia Adverse Reactionsĭermatologic: Erythema multiforme, pruritus, skin discoloration, skin photosensitivity, skin rash Propylene glycol may affect the interpretation of laboratory tests. Consider therapy modification Test Interactions Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Monitor therapyĬholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Avoid combinationīCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Drug InteractionsīCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Burned area should be covered with cream at all times reapply to areas where cream has been removed by patient activity. Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred.īurn, treatment: Infants >2 months, Children, and Adolescents: Limited data available in infants and children: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed burned area should be covered with cream at all times (Caruso 2006 de Graaf 2016, Schonfeld 1990) Administrationįor topical use only avoid contact with eyes. Note: Continue use until healing has occurred or the burn site is ready for grafting. Do not discontinue therapy if the possibility of infection exists unless a significant adverse reaction has occurred. Continue use until healing has occurred or the burn site is ready for grafting. Dosage and Administration Dosing: Adultīurn treatment: Topical: Apply to a thickness of 1/ 16 inch once or twice daily reapply as needed to areas where the cream is removed by patient activity as the burned area should be covered with cream at all times. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty. Hypersensitivity to silver sulfadiazine or any component of the formulation pregnant women approaching or at term premature infants or neonates ≤2 months of age.ĭocumentation of allergenic cross-reactivity for drugs in this class is limited. Sulfadiazine: ~24 hours (Sano 1982) Use: Labeled Indicationsīurn treatment: As an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Silver: Feces slow excretion rate Sulfadiazine: Urine (6.6% within 5 days) (Sano 1982) Half-Life Elimination Negligible (superficial and deep burns and normal skin) increased absorption with blister removal (Sano 1982) Excretion Active against Pseudomonas aeruginosa, Pseudomonas maltophilia, Enterobacter species, Klebsiella species, Serratia species, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Providencia species, Citrobacter species, Acinetobacter calcoaceticus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus species, Candida albicans, Corynebacterium diphtheriae, and Clostridium perfringens Pharmacokinetics/Pharmacodynamics Absorption ![]() Bactericidal for many gram-negative and gram-positive bacteria and is effective against yeast. Acts upon the bacterial cell wall and cell membrane.
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